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Signaling by ROS drives inflammasome activation
European Journal of Immunology · 2010 · Vol. 40(3) · pp. 616–619
Fabio Martinon✉(Harvard University)
Abstract
Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.
Inflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideIL-33, ST2, and ILC PathwaysInflammasomeNALP3BiologyAIM2Innate immune systemCell biologySignal transductionCaspase 1Immune systemImmunology
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsCarrier ProteinsHumansInflammationSignal TransductionReactive Oxygen SpeciesOxidative StressMultiprotein Complexes
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599
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45
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