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Phase III Study of Docetaxel and Cisplatin Plus Fluorouracil Compared With Cisplatin and Fluorouracil As First-Line Therapy for Advanced Gastric Cancer: A Report of the V325 Study Group
Journal of Clinical Oncology · 2006 · Vol. 24(31) · pp. 4991–4997
Eric Van Cutsem✉(Hospitais da Universidade de Coimbra)Vladimir Moiseyenko(Hospitais da Universidade de Coimbra)Sergei Tjulandin(Hospitais da Universidade de Coimbra)Alejandro Majlis(Hospitais da Universidade de Coimbra)Manuel Constenla(Hospitais da Universidade de Coimbra)C. Boni(Hospitais da Universidade de Coimbra)Adriano Rodrigues(Hospitais da Universidade de Coimbra)M Fodor(Hospitais da Universidade de Coimbra)Yee Chao(Hospitais da Universidade de Coimbra)Э К Возный(Hospitais da Universidade de Coimbra)Marie-Laure Risse(Hospitais da Universidade de Coimbra)Jaffer A. Ajani(Hospitais da Universidade de Coimbra)
Abstract
Adding docetaxel to CF significantly improved TTP, survival, and response rate in gastric cancer patients, but resulted in some increase in toxicity. Incorporation of docetaxel, as in DCF or with other active drug(s), is a new therapy option for patients with untreated advanced gastric cancer.
Gastric Cancer Management and OutcomesColorectal Cancer Treatments and StudiesCholangiocarcinoma and Gallbladder Cancer StudiesDocetaxelMedicineFluorouracilNeutropeniaInternal medicineCisplatinGastroenterologyRegimenPhases of clinical researchChemotherapy
MeSH terms
DocetaxelAdenocarcinomaAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCisplatinDrug Administration ScheduleFemaleFluorouracilHumansMaleMiddle AgedQuality of LifeStomach NeoplasmsSurvival Analysis
Funding
- Sanofi
Citations
1,929
FWCI
66.49
field-weighted impact
References
32
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100%
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