articleTop 1% cited
The Influence of Age on Propofol Pharmacodynamics
Anesthesiology · 1999 · Vol. 90(6) · pp. 1502–1516.
Thomas W. Schnider✉(University of Bern)Charles F. MintoSteven L. ShaferPedro L. GambúsCorina AndresenDavid GoodaleElizabeth Youngs
Abstract
Semilinear canonical correlation defined a new measure of propofol effect on the EEG, the canonical univariate parameter for propofol. Using this parameter, propofol plasma effect-site equilibration is faster than previously reported. This fast onset was confirmed by inspection of the EEG data. Elderly patients are more sensitive to the hypnotic and EEG effects of propofol than are younger persons.
Anesthesia and Sedative AgentsIntensive Care Unit Cognitive DisordersAnesthesia and Neurotoxicity ResearchPropofolPharmacodynamicsMedicinePharmacokineticsBolus (digestion)AnesthesiaPlasma concentrationDose–response relationshipInternal medicine
MeSH terms
AdolescentAdultAge FactorsAgedDouble-Blind MethodElectroencephalographyFemaleHumansMaleMiddle AgedModels, BiologicalPropofolCross-Over StudiesAnesthetics, Intravenous
Citations
1,057
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13.39
field-weighted impact
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25
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100%
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References
Bispectral Analysis Measures Sedation and Memory Effects of Propofol, Midazolam, Isoflurane, and Alfentanil in Healthy Volunteers
Anesthesiology · 1997 · 1,293 citations
The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers
Anesthesiology · 1998 · 1,149 citations
Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to <i>d</i>‐tubocurarine
Clinical Pharmacology & Therapeutics · 1979 · 1,139 citations
Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil
Anesthesiology · 1997 · 1,199 citations
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