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Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil

Anesthesiology · 1997 · Vol. 86(1) · pp. 10–23

Charles F. Minto✉(Stanford University)Thomas W. SchniderTalmage D. EganElizabeth YoungsHarry J. M. LemmensPedro L. GambúsV. BillardJohn F. HokeKatherine H. MooreDavid HermannKeith T. MuirJaap W. MandemaSteven L. Shafer(Stanford University)

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Abstract

This study identified (1) an effect of age on the pharmacokinetics and pharmacodynamics of remifentanil; (2) an effect of lean body mass on the pharmacokinetic parameters; and (3) no influence of gender on any pharmacokinetic or pharmacodynamic parameter.

Anesthesia and Sedative Agents Veterinary Pharmacology and Anesthesia Intensive Care Unit Cognitive DisordersRemifentanilNONMEMPharmacodynamicsMedicinePharmacokineticsAlfentanilSufentanilPopulationAnesthesiaFentanyl

MeSH terms

RemifentanilAdultAge FactorsAgedAnalgesics, OpioidFemaleHumansMaleMiddle AgedModels, BiologicalPiperidinesProspective StudiesSex FactorsAnesthetics, Intravenous

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