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The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers
Anesthesiology · 1998 · Vol. 88(5) · pp. 1170–1182
Thomas W. Schnider✉(University Hospital of Bern)Charles F. MintoPedro L. GambúsCorina AndresenDavid GoodaleSteven L. ShaferElizabeth Youngs
Abstract
These results demonstrate that method of administration (bolus vs. infusion), but not EDTA, influences the pharmacokinetics of propofol. Within the clinically relevant range, the kinetics of propofol during infusions are linear regarding infusion rate.
Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity ResearchAntibiotics Pharmacokinetics and EfficacyPropofolPharmacokineticsVolunteerMedicineBolus (digestion)AnesthesiaTarget controlled infusionIntravenous bolusCovariatePharmacology
MeSH terms
AdultAgedAgingAntidotesDouble-Blind MethodDrug InteractionsEdetic AcidFemaleHumansInfusions, IntravenousInjections, IntravenousMaleMiddle AgedPropofolCross-Over Studies
Citations
1,149
FWCI
12.26
field-weighted impact
References
32
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99%
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Citations per year
Cited by
The Influence of Age on Propofol Pharmacodynamics
Anesthesiology · 1999 · 1,057 citations
References
PHARMACOKINETIC MODEL DRIVEN INFUSION OF PROPOFOL IN CHILDREN
British Journal of Anaesthesia · 1991 · 1,180 citations
Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil
Anesthesiology · 1997 · 1,199 citations
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