article Open AccessTop 10% cited
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces
BMC Bioinformatics · 2010 · Vol. 11(1) · pp. 548–548
Hanka Venselaar✉(Radboud University Medical Center)Tim AH te Beek(Netherlands Bioinformatics Centre)Remko Kuipers(Bio-Prodict (Netherlands))Maarten L. Hekkelman(Radboud University Nijmegen)Gert Vriend(Radboud University Medical Center)
Abstract
We tested HOPE by comparing its output to the results of manually performed projects. In all straightforward cases HOPE performed similar to a trained bioinformatician. The use of 3D structures helps optimize the results in terms of reliability and details. HOPE's results are easy to understand and are presented in a way that is attractive for researchers without an extensive bioinformatics background.
Genomics and Rare DiseasesBioinformatics and Genomic NetworksGenetics, Bioinformatics, and Biomedical ResearchUniProtComputer scienceCoding (social sciences)Protein structure databaseStructural bioinformaticsBiological databaseComputational biologyProtein structureBioinformaticsData science
MeSH terms
HumansMutationProtein ConformationProteinsSoftwareUser-Computer InterfaceGenome, HumanComputational BiologyGenetic Diseases, InbornDatabases, Protein
Funding
- European Commission
- Radboud Universiteit
- Norwegian Biodiversity Information Centre
- Wageningen University and Research
- Center for Molecular Biosciences, University of Innsbruck
Citations
1,160
FWCI
10.98
field-weighted impact
References
27
Percentile
99%
vs. same field & year
Citations per year
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References
A Combined Transmembrane Topology and Signal Peptide Prediction Method
Journal of Molecular Biology · 2004 · 2,493 citations
Announcing the worldwide Protein Data Bank
Nature Structural & Molecular Biology · 2003 · 3,193 citations
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
Journal of Molecular Biology · 1999 · 3,203 citations
Basic local alignment search tool
Journal of Molecular Biology · 1990 · 93,570 citations
Increasing the precision of comparative models with YASARA NOVA—a self‐parameterizing force field
Proteins Structure Function and Bioinformatics · 2002 · 1,516 citations
Database of homology‐derived protein structures and the structural meaning of sequence alignment
Proteins Structure Function and Bioinformatics · 1991 · 1,658 citations
Improving physical realism, stereochemistry, and side‐chain accuracy in homology modeling: Four approaches that performed well in CASP8
Proteins Structure Function and Bioinformatics · 2009 · 1,421 citations
SIFT: predicting amino acid changes that affect protein function
Nucleic Acids Research · 2003 · 6,783 citations
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