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Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
Nature Structural & Molecular Biology · 2014 · Vol. 21(4) · pp. 366–374
François Aymard✉(Université Toulouse III - Paul Sabatier)Béatrix Bugler(Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération)Christine K. Schmidt(The Gurdon Institute)Emmanuelle Guillou(Université Toulouse III - Paul Sabatier)Pierre Caron(Université Toulouse III - Paul Sabatier)Sébastien Briois(Université Toulouse III - Paul Sabatier)Jason S. Iacovoni(Inserm)Virginie Daburon(Université Toulouse III - Paul Sabatier)Kyle M. Miller(The Gurdon Institute)Stephen P. Jackson(University of Cambridge)Gaëlle Legube(Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération)
DNA Repair MechanismsGenomics and Chromatin DynamicsPARP inhibition in cancer therapyRAD51Homologous recombinationChromatinBiologyHistoneDNA repairNon-homologous end joiningChromatin immunoprecipitationDNACell biology
MeSH terms
Cell LineChromatinDNA RepairDNA-Binding ProteinsHistonesHumansNeoplasm ProteinsTranscription, GeneticRad51 RecombinaseDNA Breaks, Double-StrandedHomologous RecombinationDNA End-Joining Repair
Funding
- European Molecular Biology Laboratory
- Broad Institute
Citations
661
FWCI
23.63
field-weighted impact
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52
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100%
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References
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
PLoS Biology · 2011 · 1,581 citations
An auxin-based degron system for the rapid depletion of proteins in nonplant cells
Nature Methods · 2009 · 1,817 citations
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
Nature Structural & Molecular Biology · 2010 · 614 citations
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
Nature Structural & Molecular Biology · 2010 · 1,017 citations
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