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Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
Annals of the Rheumatic Diseases · 2009 · Vol. 69(1) · pp. 88–96
Graeme Jones✉(University of Tasmania)Anthony SebbaJianhui Gu(Sun Yat-sen University)Mitchell B. LowensteinAndrea Calvo(Centro Peruano de Estudios Sociales)Juan J. Gómez‐Reino(Universidade de Santiago de Compostela)Daniel Siri(Institute of Physics Rosario)Matija Tomšič(Ljubljana University Medical Centre)Emma Alecock(Roche (United Kingdom))Thasia Woodworth(Roche (United Kingdom))M. C. Genovese(Stanford University)
Abstract
Tocilizumab monotherapy is better than methotrexate monotherapy, with rapid improvement in RA signs and symptoms, and a favourable benefit-risk, in patients for whom treatment with methotrexate or biological agents has not previously failed.
Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders ResearchSystemic Lupus Erythematosus ResearchTocilizumabMedicineRheumatoid arthritisMethotrexateInternal medicineNeutropeniaRheumatologyPlaceboGastroenterologyAdverse effect
MeSH terms
AdultAgedAntibodies, MonoclonalArthritis, RheumatoidC-Reactive ProteinDouble-Blind MethodFemaleHumansImmunosuppressive AgentsMaleMethotrexateMiddle AgedSeverity of Illness IndexBiomarkersTreatment Outcome
Funding
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- Servier
- Genentech
Citations
804
FWCI
39.91
field-weighted impact
References
44
Percentile
100%
vs. same field & year
Citations per year
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References
The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
Arthritis & Rheumatism · 2005 · 1,780 citations
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial
Arthritis & Rheumatism · 2004 · 1,168 citations
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
Annals of the Rheumatic Diseases · 2009 · 804 citations
Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
Arthritis & Rheumatism · 1995 · 6,175 citations
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
Annals of the Rheumatic Diseases · 2008 · 1,104 citations
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
Annals of the Rheumatic Diseases · 2007 · 740 citations
American college of rheumatology preliminary definition of improvement in rheumatoid arthritis
Arthritis & Rheumatism · 1995 · 2,833 citations
Guidelines for the management of rheumatoid arthritis: 2002 Update
Arthritis & Rheumatism · 2002 · 1,211 citations
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