articleTop 1% cited
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial
Arthritis & Rheumatism · 2004 · Vol. 50(5) · pp. 1400–1411
Edward Keystone✉(University of Toronto)Arthur F. Kavanaugh(University of California, San Diego)John T. Sharp(University of Washington)H Tannenbaum(McGill University)Hua Ye(Abbott (United States))Leah Teoh(Abbott (United States))Steven Fischkoff(Reckitt Benckiser (United States))Elliot Chartash(Abbott (United States))
Abstract
In this 52-week trial, adalimumab was more effective than placebo at inhibiting the progression of structural joint damage, reducing the signs and symptoms, and improving physical function in patients with active RA who had demonstrated an incomplete response to MTX.
Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders ResearchSystemic Lupus Erythematosus ResearchAdalimumabMedicineRheumatoid arthritisConcomitantInternal medicinePlaceboRheumatologyMethotrexateInfliximabGastroenterology
MeSH terms
AdalimumabActivities of Daily LivingAdultAgedAntibodies, MonoclonalArthritis, RheumatoidDrug Therapy, CombinationFemaleHumansMaleMethotrexateMiddle AgedPlacebosQuality of LifeRadiography
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