article Open AccessTop 1% cited
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
Annals of the Rheumatic Diseases · 2008 · Vol. 67(11) · pp. 1516–1523
Paul Emery✉(University of Leeds)Edward Keystone(Mount Sinai Hospital)Hans‐Peter Tony(Klinikum Würzburg Mitte)Alain Cantagrel(Hôpital Rangueil)Ronald van Vollenhoven(Karolinska University Hospital)Antonio Sánchez(Hospital de Especialidades)Emma Alecock(Roche (United Kingdom))J. Lee(La Roche College)Joel M. Kremer(Albany Medical Center Hospital)
Abstract
NCT00106522.
Rheumatoid Arthritis Research and TherapiesToxin Mechanisms and ImmunotoxinsAutoimmune and Inflammatory Disorders ResearchMedicineTocilizumabRheumatoid arthritisInternal medicineAdverse effectPlaceboGastroenterologyRashMethotrexateRefractory (planetary science)
MeSH terms
AdolescentAdultAgedAntibodies, MonoclonalArthritis, RheumatoidDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMethotrexateMiddle AgedSeverity of Illness IndexTumor Necrosis Factor-alpha
Funding
- Chugai Pharmaceutical
Citations
1,104
FWCI
59.13
field-weighted impact
References
62
Percentile
100%
vs. same field & year
Citations per year
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Circulation · 2004 · 6,919 citations
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Journal of Clinical Investigation · 2004 · 2,225 citations
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
Annals of the Rheumatic Diseases · 2007 · 740 citations
Collagen-induced arthritis
Nature Protocols · 2007 · 1,401 citations
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Journal of Clinical Investigation · 2004 · 2,111 citations
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