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Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline

The Journal of Clinical Endocrinology & Metabolism · 2011 · Vol. 96(6) · pp. 1587–1609

Mark E. Molitch✉(Northwestern University)David R. Clemmons(University of North Carolina at Chapel Hill)Saúl Malozowski(National Institutes of Health)George R. Merriam(University of Washington Tacoma)Mary Lee Vance(University of Virginia)

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Abstract

GHD can persist from childhood or be newly acquired. Confirmation through stimulation testing is usually required unless there is a proven genetic/structural lesion persistent from childhood. GH therapy offers benefits in body composition, exercise capacity, skeletal integrity, and quality of life measures and is most likely to benefit those patients who have more severe GHD. The risks associated with GH treatment are low. GH dosing regimens should be individualized. The final decision to treat adults with GHD requires thoughtful clinical judgment with a careful evaluation of the benefits and risks specific to the individual.

Growth Hormone and Insulin-like Growth Factors Pituitary Gland Disorders and Treatments Diet and metabolism studiesGuidelineEndocrine systemMedicineGrowth hormone deficiencyDosingGrowth hormoneClinical PracticeClinical trialIntensive care medicinePediatrics