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The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition

Clinical Endocrinology · 1992 · Vol. 37(1) · pp. 79–87

Arjen Binnerts(Rotterdam University of Applied Sciences)G. Roel Swart(Rotterdam University of Applied Sciences)J. H. P. Wilson(Rotterdam University of Applied Sciences)Nicoline Hoogerbrugge(Rotterdam University of Applied Sciences)Hulbert A. P. Pois(Rotterdam University of Applied Sciences)J.C. Birkenhäger(Rotterdam University of Applied Sciences)Steven W. J. Lamberts✉(Rotterdam University of Applied Sciences)

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Abstract

Therapy with growth hormone for 6 months in a dose varying between 6 and 25 micrograms/kg/day increased lean body mass and decreased fat mass. The sense of general well-being improved in most patients. Furthermore, growth hormone treatment increased bone turnover without a measurable increase in bone density, caused some minor changes in lipid and carbohydrate metabolism, and increased the metabolism of thyroxine to T3.

Growth Hormone and Insulin-like Growth Factors Nutrition and Health in Aging Diet and metabolism studiesInternal medicineEndocrinologyOsteocalcinHomeostasisHormoneLean body massGlucose homeostasisNitrogen balanceExcretionHydroxyproline