article Open AccessTop 1% cited
variancePartition: interpreting drivers of variation in complex gene expression studies
BMC Bioinformatics · 2016 · Vol. 17(1) · pp. 483–483
Gabriel E. Hoffman✉(Icahn School of Medicine at Mount Sinai)Eric E. Schadt(Icahn School of Medicine at Mount Sinai)
Abstract
Our open source software, variancePartition, enables rapid interpretation of complex gene expression studies as well as other high-throughput genomics assays. variancePartition is available from Bioconductor: http://bioconductor.org/packages/variancePartition .
Gene expression and cancer classificationGenetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and AnimalsDNA microarrayVariation (astronomy)Gene expressionComputational biologyBiologyExpression (computer science)GeneGeneticsGene expression profilingBioinformatics
MeSH terms
AlgorithmsGene Expression RegulationHumansSoftwareGenetic VariationLinear ModelsSequence Analysis, RNAComputational BiologyGene Expression ProfilingGenomicsHigh-Throughput Nucleotide Sequencing
Funding
- Icahn School of Medicine at Mount Sinai
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
Citations
848
FWCI
15.49
field-weighted impact
References
62
Percentile
99%
vs. same field & year
Citations per year
References
Mixed-Effects Models in S and S-PLUS
Technometrics · 2001 · 9,355 citations
Genome-wide efficient mixed-model analysis for association studies
Nature Genetics · 2012 · 3,909 citations
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
BMC Bioinformatics · 2011 · 22,985 citations
Random-Effects Models for Longitudinal Data
Biometrics · 1982 · 8,821 citations
Variance component model to account for sample structure in genome-wide association studies
Nature Genetics · 2010 · 3,011 citations
<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data
Bioinformatics · 2009 · 43,721 citations
HTSeq—a Python framework to work with high-throughput sequencing data
Bioinformatics · 2014 · 22,334 citations
voom: precision weights unlock linear model analysis tools for RNA-seq read counts
Genome biology · 2014 · 6,605 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
