review Open AccessTop 1% cited
Finding the missing heritability of complex diseases
Nature · 2009 · Vol. 461(7265) · pp. 747–753
Teri A. Manolio✉(National Institutes of Health)Francis S. Collins(National Institutes of Health)Nancy J. Cox(University of Chicago)David B. Goldstein(Duke University)Lucia A. Hindorff(National Human Genome Research Institute)David J. Hunter(Harvard University Press)Mark I. McCarthy(University of Oxford)Erin M. Ramos(National Institutes of Health)Lon R. Cardon(GlaxoSmithKline (Netherlands))Aravinda Chakravarti(Johns Hopkins University)Judy H. Cho(Yale University)Alan E. Guttmacher(National Human Genome Research Institute)Augustine Kong(deCODE Genetics (Iceland))Leonid Kruglyak(Princeton University)Elaine R. Mardis(Washington University in St. Louis)Charles N. Rotimi(National Institutes of Health)Montgomery Slatkin(University of California, Berkeley)David Valle(Johns Hopkins Medicine)Alice S. Whittemore(Stanford University)Michael Boehnke(University of Michigan–Ann Arbor)Andrew G. Clark(Cornell University)Evan E. Eichler(University of Washington)Greg Gibson(University of Queensland)Jonathan L. Haines(Vanderbilt University)Trudy F. C. Mackay(North Carolina State University)Steven A. McCarroll(Harvard University Press)Peter M. Visscher(QIMR Berghofer Medical Research Institute)
Genetic Associations and EpidemiologyGenomic variations and chromosomal abnormalitiesGenomics and Rare DiseasesMissing heritability problemHeritabilityGenome-wide association studyGenetic architectureGenetic associationBiologyGeneticsDiseaseEvolutionary biologyComputational biology
MeSH terms
Genetics, MedicalHumansPedigreeGenetic Predisposition to DiseaseGenetic Diseases, InbornInheritance PatternsGenome-Wide Association Study
Citations
8,468
FWCI
364.82
field-weighted impact
References
84
Percentile
100%
vs. same field & year
Citations per year
Cited by
Review on genetic-environmental interaction (GxE) and its application in crop breeding
International Journal of Research in Agronomy · 2022 · 6 citations
Research Review: Polygenic methods and their application to psychiatric traits
Journal of Child Psychology and Psychiatry · 2014 · 706 citations
Alzheimer’s Disease: The Challenge of the Second Century
Science Translational Medicine · 2011 · 1,414 citations
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
Endocrine Reviews · 2012 · 1,838 citations
Molecular pathways of nonalcoholic fatty liver disease development and progression
Cellular and Molecular Life Sciences · 2018 · 588 citations
Genetics and intelligence differences: five special findings
Molecular Psychiatry · 2014 · 712 citations
Missing heritability and strategies for finding the underlying causes of complex disease
Nature Reviews Genetics · 2010 · 1,747 citations
Improved Heritability Estimation from Genome-wide SNPs
The American Journal of Human Genetics · 2012 · 834 citations
References
Prediction of Total Genetic Value Using Genome-Wide Dense Marker Maps
Genetics · 2001 · 7,802 citations
Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings
PLoS Genetics · 2006 · 650 citations
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Science · 1993 · 9,373 citations
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
Nature Reviews Genetics · 2008 · 2,943 citations
Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data
The American Journal of Human Genetics · 2008 · 1,605 citations
Advances in autism genetics: on the threshold of a new neurobiology
Nature Reviews Genetics · 2008 · 1,856 citations
Heritability in the genomics era — concepts and misconceptions
Nature Reviews Genetics · 2008 · 1,936 citations
On the allelic spectrum of human disease
Trends in Genetics · 2001 · 1,186 citations
Related articles
Finding the missing heritability of complex diseases
Nature · 2009 · 8,468 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.