review Open AccessTop 1% cited

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

Neuron · 2015 · Vol. 85(2) · pp. 257–273

Alicia M. Pickrell✉(National Institute of Neurological Disorders and Stroke)Richard J. Youle(National Institute of Neurological Disorders and Stroke)

View via DOI Full-text PDF

Parkinson's Disease Mechanisms and Treatments Autophagy in Disease and Therapy Mitochondrial Function and PathologyPINK1ParkinNeuroscienceParkinson's diseaseDiseaseMitochondrionMitophagyMedicineBiologyAutophagy

MeSH terms

PTEN-Induced Putative KinaseHumansMitochondriaParkinson DiseaseProtein KinasesParkinsonian DisordersUbiquitin-Protein LigasesProteolysisMitophagy

Funding

National Institutes of Health
National Institute of General Medical Sciences
National Institute of Neurological Disorders and Stroke

Citations

2,161

FWCI

117.86

field-weighted impact

References

212

Percentile

100%

vs. same field & year

Citations per year

Cited by

Mitochondria in crisis: The hidden engine of neurodegenration

International Journal of Pharmacology and Clinical Research · 2025 · 0 citations

Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects

Cells · 2019 · 458 citations

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Molecules · 2019 · 2,145 citations

Mitochondrial dysfunction in Parkinson's disease

Journal of Neurochemistry · 2016 · 831 citations

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Current Biology · 2018 · 1,933 citations

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease

Cell Death and Disease · 2022 · 402 citations

Parkinson's disease: Mechanisms, translational models and management strategies

Life Sciences · 2019 · 591 citations

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

Frontiers in Neuroscience · 2018 · 359 citations

References

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Nature Neuroscience · 2000 · 3,655 citations

Rotenone, Paraquat, and Parkinson’s Disease

Environmental Health Perspectives · 2011 · 1,427 citations

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Nature Cell Biology · 2010 · 2,752 citations

Mechanisms of mitophagy

Nature Reviews Molecular Cell Biology · 2010 · 3,157 citations

Mitochondrial Complex I Deficiency in Parkinson's Disease

Journal of Neurochemistry · 1990 · 2,261 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Life Sciences · 1985 · 1,254 citations

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Human Molecular Genetics · 2010 · 891 citations

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

PLoS Biology · 2010 · 2,862 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.