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Mechanisms of mitophagy

Nature Reviews Molecular Cell Biology · 2010 · Vol. 12(1) · pp. 9–14
Richard J. Youle✉Derek P. Narendra
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Autophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders ResearchMitophagyPINK1ParkinAutophagyCell biologyMitochondrionBiologyBAG3LysosomeGenetics

MeSH terms

AnimalsAutophagyErythrocytesHumansMitochondriaModels, Biological

Funding

  • National Institutes of Health
Citations
3,157
FWCI
87.48
field-weighted impact
References
72
Percentile
100%
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Citations per year
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References
Eaten alive: a history of macroautophagy
Nature Cell Biology · 2010 · 2,075 citations
Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
Developmental Cell · 2009 · 862 citations
Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy
Developmental Cell · 2009 · 797 citations
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Journal of Biological Chemistry · 2007 · 4,501 citations
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Nature Cell Biology · 2010 · 2,752 citations
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
Human Molecular Genetics · 2010 · 891 citations
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
PLoS Biology · 2010 · 2,862 citations
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
The Journal of Cell Biology · 2008 · 1,795 citations
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