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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Nature Cell Biology · 2010 · Vol. 12(2) · pp. 119–131
Sven GeislerKira M. HolmströmDiana SkujatFabienne C. FieselOliver C. RothfussPhilipp J. KahleWolfdieter Springer
Autophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathwaysParkinPINK1MitophagyVDAC1AutophagyUbiquitin ligaseCell biologyUbiquitinMitochondrionBiology

MeSH terms

Sequestosome-1 ProteinPTEN-Induced Putative KinaseAutophagyBiological TransportFluorescent Antibody TechniqueHeLa CellsHumansMitochondriaMutationParkinson DiseaseProtein KinasesImmunoblottingRNA InterferenceUbiquitin-Protein LigasesCell Line, Tumor
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