articleTop 1% cited
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
Life Sciences · 1985 · Vol. 36(26) · pp. 2503–2508
William J. Nicklas✉(Rutgers, The State University of New Jersey)I Vyas(Rutgers, The State University of New Jersey)Richard E. Heikkila(Rutgers, The State University of New Jersey)
Neuroscience and Neuropharmacology ResearchParkinson's Disease Mechanisms and TreatmentsElectrochemical Analysis and ApplicationsMPTPNeurotoxinMetaboliteMitochondrionChemistryOxidative phosphorylationBiochemistryGlutamate receptorStereochemistryDopamine
MeSH terms
Adenosine DiphosphateAnimalsBrainGlutamatesMalatesMaleMitochondriaNADNeurotoxinsOxidation-ReductionPhosphorylationPyridinesRats, Inbred Strains1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineGlutamic Acid
Citations
1,254
FWCI
10.45
field-weighted impact
References
12
Percentile
99%
vs. same field & year
Citations per year
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References
Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey
Brain Research · 1984 · 918 citations
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
Biochemical and Biophysical Research Communications · 1984 · 1,093 citations
Chronic parkinsonism secondary to intravenous injection of meperidine analogues
Psychiatry Research · 1979 · 1,361 citations
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