article Open AccessTop 1% cited
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
Current Biology · 1998 · Vol. 8(5) · pp. 279–282
Homayoun Vaziri(Ontario Institute for Cancer Research)Samuel Benchimol✉(Ontario Institute for Cancer Research)
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsBiologyTelomereTelomeraseLife spanElongationCell biologyGeneticsEvolutionary biologyDNAGene
MeSH terms
AnimalsCatalysisCells, CulturedDNA ReplicationDNA-Binding ProteinsFibroblastsHumansProtein ConformationProteinsRetroviridaeRNATetrahymenaTelomereCellular SenescenceTelomerase
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References
A theory of marginotomy
Journal of Theoretical Biology · 1973 · 1,816 citations
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
The EMBO Journal · 1992 · 2,105 citations
The serial cultivation of human diploid cell strains
Experimental Cell Research · 1961 · 8,329 citations
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Proceedings of the National Academy of Sciences · 1995 · 7,364 citations
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