article Open AccessTop 1% cited
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
Cell · 1997 · Vol. 88(5) · pp. 593–602
Manuel Serrano(Howard Hughes Medical Institute)Athena W. Lin(Cold Spring Harbor Laboratory)Mila E. McCurrach(Cold Spring Harbor Laboratory)David Beach✉(Howard Hughes Medical Institute)Scott Lowe(Cold Spring Harbor Laboratory)
Cancer-related Molecular PathwaysTelomeres, Telomerase, and SenescenceRetinoids in leukemia and cellular processesBiologySenescenceCarcinogenesisCell biologySuppressorOncogeneCellCell cycleCancer researchGenetics
MeSH terms
AnimalsCarrier ProteinsEnzyme InhibitorsFibroblastsHumansMice, Mutant StrainsOncogenesRNA, MessengerTransformation, GeneticImmunoblottingBlotting, NorthernBiomarkersGene Expression Regulation, NeoplasticGenes, Tumor SuppressorTumor Suppressor Protein p53
Funding
- National Institutes of Health
- National Cancer Institute
Citations
5,018
FWCI
62.97
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References
82
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100%
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References
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
Cell · 1995 · 4,588 citations
The multistep nature of cancer
Trends in Genetics · 1993 · 1,857 citations
The retinoblastoma protein and cell cycle control
Cell · 1995 · 4,876 citations
The serial cultivation of human diploid cell strains
Experimental Cell Research · 1961 · 8,329 citations
Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
Experimental Cell Research · 1994 · 1,347 citations
Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development · 1995 · 3,256 citations
Tumor spectrum analysis in p53-mutant mice
Current Biology · 1994 · 2,066 citations
Lessons from Hereditary Colorectal Cancer
Cell · 1996 · 4,911 citations
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