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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
Pharmaceutical Research · 2013 · Vol. 30(9) · pp. 2174–2187
Mitchell R. McGill✉Hartmut Jaeschke(University of Kansas Medical Center)
Drug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsGlutathioneChemistryMultidrug resistance-associated protein 2GlucuronidationAcetaminophenCytochrome P450Drug metabolismMetaboliteCYP2E1Metabolism
MeSH terms
AcetaminophenAnimalsCytochrome P-450 Enzyme SystemGlutathione TransferaseHumansLiverProtein BindingAnalgesics, Non-NarcoticChemical and Drug Induced Liver InjuryAntipyretics
Funding
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Environmental Health Sciences
Citations
684
FWCI
50.11
field-weighted impact
References
185
Percentile
100%
vs. same field & year
Citations per year
References
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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
Toxicology and Applied Pharmacology · 2012 · 413 citations
ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM
Journal of Pharmacology and Experimental Therapeutics · 1973 · 1,493 citations
ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. II. ROLE OF COVALENT BINDING IN VIVO
Journal of Pharmacology and Experimental Therapeutics · 1973 · 1,202 citations
Acetaminophen‐induced acute liver failure
Hepatology · 2005 · 1,913 citations
ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE
Journal of Pharmacology and Experimental Therapeutics · 1973 · 1,745 citations
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