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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

Toxicology and Applied Pharmacology · 2012 · Vol. 264(3) · pp. 387–394

Mitchell R. McGill(University of Kansas Medical Center)C. David Williams(University of Kansas Medical Center)Yuchao Xie(University of Kansas)Anup Ramachandran(University of Kansas Medical Center)Hartmut Jaeschke✉(University of Kansas)

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Drug-Induced Hepatotoxicity and Protection Liver Disease and Transplantation Liver Disease Diagnosis and TreatmentAcetaminophenToxicityOxidative stressLiver injuryPharmacologyMitochondrionMechanism (biology)MedicineMetabolismChemistry

MeSH terms

AcetaminophenAlanine TransaminaseAnimalsDisease Models, AnimalGene Expression RegulationGlutamate DehydrogenaseMice, Inbred C57BLMitochondriaProtein BindingRats, Inbred F344Time FactorsRats, Sprague-DawleyOxidative StressAnalgesics, Non-NarcoticMitochondrial Proteins

Funding

McGill University
National Institutes of Health
National Institute of General Medical Sciences
National Institute of Environmental Health Sciences

Citations

413

FWCI

29.56

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

Pharmaceutical Research · 2013 · 684 citations

References

ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

Journal of Pharmacology and Experimental Therapeutics · 1973 · 1,493 citations

Acetaminophen‐induced acute liver failure

Hepatology · 2005 · 1,913 citations

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