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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

Journal of Pharmacology and Experimental Therapeutics · 1973 · Vol. 187(1) · pp. 185–194
Drug-Induced Hepatotoxicity and ProtectionPoisoning and overdose treatmentsCannabis and Cannabinoid ResearchAcetaminophenNecrosisMetaboliteCentrilobular necrosisPharmacologyFulminant hepatic failureChemistryDrug metabolismMetabolismPhenobarbital

MeSH terms

AcetaminophenAnimalsCobaltDose-Response Relationship, DrugDrug SynergismKidneyLethal Dose 50LiverMaleMethylcholanthreneMice, Inbred StrainsNecrosisPhenobarbitalPiperonyl ButoxideSpecies Specificity
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