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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Cell Metabolism · 2015 · Vol. 21(1) · pp. 65–80

Eva M. Pålsson‐McDermott(Trinity College Dublin)Annie M. Curtis(Trinity College Dublin)Gautam Goel(Harvard University)Mario Lauterbach(Trinity College Dublin)Frederick J. Sheedy(Trinity College Dublin)Laura E. Gleeson(Trinity College Dublin)Mirjam W.M. van den Bosch(Trinity College Dublin)Susan R. Quinn(Trinity College Dublin)Raquel Domingo-Fernandéz(Trinity College Dublin)Daniel Johnston(Trinity College Dublin)Jian‐kang Jiang(National Center for Advancing Translational Sciences)William J. Israelsen(Massachusetts Institute of Technology)Joseph Keane(Trinity College Dublin)Craig J. Thomas(National Institutes of Health)Clary B. Clish(Broad Institute)Matthew G. Vander Heiden(Dana-Farber Cancer Institute)Ramnik J. Xavier(Massachusetts General Hospital)Luke O'neill✉(Trinity College Dublin)

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Immune cells in cancer Erythrocyte Function and Pathophysiology Cancer, Hypoxia, and MetabolismWarburg effectCell biologyPyruvate kinaseGlycolysisKinaseChemistryBiologyCancer researchMetabolismBiochemistry

MeSH terms

AnimalsBone Marrow CellsCells, CulturedGlycolysisLipopolysaccharidesMacrophage ActivationMacrophagesMice, Inbred C57BLPromoter Regions, GeneticProtein BindingPyruvate KinaseRNA, MessengerSalmonella typhimuriumGene ExpressionEnzyme Activators

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