reviewTop 1% cited
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Trends in Neurosciences · 2001 · Vol. 24(4) · pp. 219–224
William L. Klein✉(Northwestern University)
Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsCholinesterase and Neurodegenerative DiseasesFibrilSenile plaquesNeurotoxinDiseaseAmyloid (mycology)Amyloid fibrilNeurosciencePeptideAlzheimer's diseaseChemistry
MeSH terms
Alzheimer DiseaseAnimalsAntibodiesHippocampusMice, TransgenicPeptide FragmentsVaccinesSignal TransductionAmyloid beta-PeptidesAmyloid beta-Protein PrecursorSynaptophysinLong-Term PotentiationMicePlaque, Amyloid
Citations
994
FWCI
24.55
field-weighted impact
References
47
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100%
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References
High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
Journal of Neuroscience · 2000 · 1,860 citations
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
Journal of Neuroscience · 1993 · 1,424 citations
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Biochemical and Biophysical Research Communications · 1984 · 5,345 citations
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
American Journal Of Pathology · 1999 · 1,521 citations
Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
Annals of Neurology · 1999 · 1,797 citations
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
Nature Medicine · 1996 · 2,586 citations
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Journal of Neuroscience · 1996 · 1,809 citations
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