reviewTop 1% cited
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Oncogene · 2007 · Vol. 26(22) · pp. 3291–3310
Patrick J. Roberts✉Channing J. Der(University of North Carolina at Chapel Hill)
Melanoma and MAPK PathwaysSynthesis and biological activityProtein Kinase Regulation and GTPase SignalingMAPK/ERK pathwayAnti-apoptotic Ras signalling cascadeBiologyCancer researchCell biologyProtein kinase ASignal transductionKinaseAutocrine signallingReceptor
MeSH terms
AnimalsHumansNeoplasmsDrug Delivery SystemsMAP Kinase Kinase KinasesMAP Kinase Signaling SystemExtracellular Signal-Regulated MAP Kinasesraf Kinases
Funding
- National Institutes of Health
Citations
2,782
FWCI
55.22
field-weighted impact
References
151
Percentile
100%
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Citations per year
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Experimental Cell Research · 2003 · 588 citations
ERBB receptors and cancer: the complexity of targeted inhibitors
Nature reviews. Cancer · 2005 · 3,292 citations
Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer
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Cancer Statistics, 2005
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