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Hyperfibrinolysis After Major Trauma: Differential Diagnosis of Lysis Patterns and Prognostic Value of Thrombelastometry

Abstract

ROTEM-based diagnosis of HF predicted outcome. Further independent predictors of death were combination of HF with hemorrhagic shock, low PC, and prolonged CFT in ROTEM. ROTEM-based point of care testing in the emergency room is thus able to identify prognostic factors such as prolonged CFT and low platelet contribution to clot firmness (MCF(EX) - MCF(FIB)) earlier than standard laboratory-based monitoring.

Trauma, Hemostasis, Coagulopathy, ResuscitationTrauma and Emergency Care StudiesAbdominal Trauma and InjuriesHyperfibrinolysisValue (mathematics)MedicineInternal medicineDifferential (mechanical device)Differential diagnosisCardiologyPathologyMathematicsFibrinolysis

MeSH terms

AdultAgedAged, 80 and overBlood Coagulation DisordersBlood Coagulation FactorsDiagnosis, DifferentialFemaleFibrinolysisFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSensitivity and Specificity
Citations
396
FWCI
18.35
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37
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100%
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References
Acute Traumatic Coagulopathy
The Journal of Trauma: Injury, Infection, and Critical Care · 2003 · 1,708 citations
Epidemiology of trauma deaths
The American Journal of Surgery · 1980 · 848 citations
A Systematic Evaluation of the Effect of Temperature on Coagulation Enzyme Activity and Platelet Function
The Journal of Trauma: Injury, Infection, and Critical Care · 2004 · 525 citations
Evaluating Trauma Care
The Journal of Trauma: Injury, Infection, and Critical Care · 1987 · 1,798 citations
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