articleTop 1% cited

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

European Journal of Cancer · 1998 · Vol. 34(8) · pp. 1274–1281

Masanori Miwa(Nippon Electric Glass (Japan))Masako UraM NishidaNoriaki SawadaT IshikawaKazushige MoriNobuo ShimmaIsao UMEDAHideo Ishitsuka✉

View via DOI Publisher page

Colorectal Cancer Treatments and Studies Cancer Treatment and Pharmacology Cancer, Hypoxia, and MetabolismCapecitabineThymidine phosphorylaseCytotoxicityCytidine deaminaseCancer researchPharmacologyCancerCarboxylesteraseFluorouracilLiver cancer

MeSH terms

CapecitabineAnimalsCarboxylic Ester HydrolasesCytidine DeaminaseDeoxycytidineFemaleFloxuridineFluorouracilHumansLiverMaleNeoplasmsThymidine PhosphorylaseMice

Citations

1,233

FWCI

12.45

field-weighted impact

References

Percentile

99%

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Citations per year

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References

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Journal of Biological Chemistry · 1951 · 317,666 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Journal of Immunological Methods · 1983 · 55,054 citations

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