reviewTop 1% cited
5-Fluorouracil: mechanisms of action and clinical strategies
Nature reviews. Cancer · 2003 · Vol. 3(5) · pp. 330–338
Daniel B. Longley✉D. Paul Harkin(Queen's University Belfast)Patrick G. Johnston(Queen's University Belfast)
Colorectal Cancer Treatments and StudiesGenetic factors in colorectal cancerCholangiocarcinoma and Gallbladder Cancer StudiesFluorouracilMicroarrayDrug resistanceChemotherapyMechanism (biology)Cancer researchComputational biologyBioinformaticsMedicineGene
MeSH terms
AnimalsAntimetabolites, AntineoplasticFluorouracilHumansInterferonsOxidoreductasesRNAThymidine PhosphorylaseThymidylate SynthaseBiomarkersTumor Suppressor Protein p53Microsatellite RepeatsOligonucleotide Array Sequence AnalysisDihydrouracil Dehydrogenase (NADP)
Citations
5,181
FWCI
24.77
field-weighted impact
References
111
Percentile
100%
vs. same field & year
Citations per year
Cited by
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
Molecules · 2008 · 764 citations
Apoptosis and Molecular Targeting Therapy in Cancer
BioMed Research International · 2014 · 1,106 citations
Chemotherapy Side-Effects: Not All DNA Damage Is Equal
Cancers · 2022 · 418 citations
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
Chemical Reviews · 2013 · 4,668 citations
5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity
Cancer Research · 2010 · 1,212 citations
Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells
BMC Cancer · 2010 · 316 citations
Molecular mechanisms of drug resistance
The Journal of Pathology · 2005 · 1,646 citations
Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle
Dalton Transactions · 2012 · 694 citations
References
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
European Journal of Cancer · 1998 · 1,233 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.