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Efficacy of Naltrexone and Acamprosate for Alcoholism Treatment: A Meta‐Analysis

Alcoholism Clinical and Experimental Research · 2001 · Vol. 25(9) · pp. 1335–1341

Henry R. Kranzler✉(University of Connecticut)Jeffrey Van Kirk(University of Connecticut)

Abstract

Both naltrexone and acamprosate are efficacious in reducing alcohol consumption in alcoholics. However, their specific role in alcoholism treatment remains to be more clearly defined. New approaches to the use of these medications and development of new medications are needed if pharmacotherapy is to play a substantial role in the treatment of alcoholism.

Treatment of Major Depression Neurotransmitter Receptor Influence on Behavior Substance Abuse Treatment and OutcomesAcamprosateNaltrexoneAlcohol dependencePlaceboMeta-analysisPsychiatryMedicineAlcohol use disorderAlcoholPsychology

MeSH terms

AcamprosateAlcohol DeterrentsAlcoholismDepressionFemalegamma-GlutamyltransferaseHumansMaleNaltrexoneNarcotic AntagonistsPlacebosTaurineTreatment OutcomeSelective Serotonin Reuptake InhibitorsSecondary Prevention

Citations

392

FWCI

17.63

field-weighted impact

References

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100%

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Meta‐analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful?