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Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review

Addiction · 2004 · Vol. 99(7) · pp. 811–828

Bouza Carmen✉(Agencia de Evaluación de Tecnologías Sanitarias)Angeles Magro(Agencia de Evaluación de Tecnologías Sanitarias)Muñoz Ana(Agencia de Evaluación de Tecnologías Sanitarias)Amate José María(Agencia de Evaluación de Tecnologías Sanitarias)

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Abstract

Both acamprosate and naltrexone are effective as adjuvant therapies for alcohol dependence in adults. Acamprosate appears to be especially useful in a therapeutic approach targeted at achieving abstinence, whereas naltrexone seems more indicated in programmes geared to controlled consumption. Both drugs are safe and acceptably tolerated but issues of compliance need to be addressed adequately to assure their usefulness in clinical practice.

Substance Abuse Treatment and Outcomes Opioid Use Disorder Treatment Schizophrenia research and treatmentAcamprosateNaltrexoneAbstinenceAlcohol dependenceMedicineRelapse preventionRandomized controlled trialMeta-analysisPsychiatryInternal medicine