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Meta‐analysis of naltrexone and acamprosate for treating alcohol use disorders: when are these medications most helpful?

Addiction · 2012 · Vol. 108(2) · pp. 275–293

Natalya C. Maisel✉(VA Palo Alto Health Care System)Janet C. Blodgett(VA Palo Alto Health Care System)Paula Wilbourne(VA Palo Alto Health Care System)Keith Humphreys(Stanford University)John W. Finney(Stanford University)

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Abstract

In treatment for alcohol use disorders, acamprosate has been found to be slightly more efficacious in promoting abstinence and naltrexone slightly more efficacious in reducing heavy drinking and craving. Detoxification before treatment or a longer period of required abstinence before treatment is associated with larger medication effects for acamprosate and naltrexone respectively.

Substance Abuse Treatment and Outcomes Opioid Use Disorder Treatment Neurotransmitter Receptor Influence on BehaviorAcamprosateNaltrexoneAbstinenceCravingPlaceboAlcohol dependenceRelapse preventionMedicinePsychiatryRandomized controlled trial

MeSH terms

AcamprosateAlcohol DeterrentsEthanolHumansInactivation, MetabolicNaltrexoneNarcotic AntagonistsTaurineTime FactorsRandomized Controlled Trials as TopicTreatment OutcomeAlcohol-Related Disorders

Citations

456

FWCI

16.64

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

References

The file drawer problem and tolerance for null results.