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A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients
Neuropsychopharmacology · 2003 · Vol. 28(8) · pp. 1546–1552
David W. Oslin✉(University of Pennsylvania)Wade H. Berrettini(University of Pennsylvania)Henry R. Kranzler(University of Connecticut)Helen M. Pettinati(University of Pennsylvania)Joel Gelernter(Yale University)Joseph R. Volpicelli(University of Pennsylvania)Charles P. O’Brien(Mental Illness Research, Education and Clinical Centers)
Opioid Use Disorder TreatmentPain Management and Opioid UseNeuropeptides and Animal PhysiologyNaltrexonePlaceboAlcohol dependenceOpioidInternal medicineGenotypeOpioid receptorSingle-nucleotide polymorphismAbstinenceMedicine
MeSH terms
AdultAlcoholismFemaleGene FrequencyHumansMaleMiddle AgedNaltrexonePolymorphism, GeneticConfidence IntervalsLogistic ModelsOdds RatioSurvival AnalysisReceptors, Opioid, mu
Funding
- U.S. Department of Veterans Affairs
- University of Pennsylvania
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- U.S. Public Health Service
- NIH Clinical Center
Citations
574
FWCI
32.08
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
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References
An Improved Diagnostic Evaluation Instrument for Substance Abuse Patients
The Journal of Nervous and Mental Disease · 1980 · 3,209 citations
Efficacy of Naltrexone and Acamprosate for Alcoholism Treatment: A Meta‐Analysis
Alcoholism Clinical and Experimental Research · 2001 · 392 citations
Naltrexone and Coping Skills Therapy for Alcohol Dependence
Archives of General Psychiatry · 1992 · 1,507 citations
Naltrexone in the Treatment of Alcohol Dependence
Archives of General Psychiatry · 1992 · 1,857 citations
New Data from the Addiction Severity Index Reliability and Validity in Three Centers
The Journal of Nervous and Mental Disease · 1985 · 1,519 citations
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