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Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

Biological Psychiatry · 2007 · Vol. 63(4) · pp. 349–352

Sungho Maeng✉Carlos A. Zarate(National Institute of Mental Health)Jing Du(National Institute of Mental Health)Robert J. Schloesser(National Institutes of Health)Joseph McCammon(National Institutes of Health)Guang Chen(National Institutes of Health)Husseini K. Manji(National Institutes of Health)

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Treatment of Major Depression Tryptophan and brain disorders Neuroscience and Neuropharmacology ResearchNBQXAMPA receptorNMDA receptorKetamineAntidepressantPharmacologyDizocilpineGlutamate receptorAntagonistBehavioural despair test

MeSH terms

AnimalsDepressive Disorder, MajorMajor Depressive DisorderHelplessness, LearnedHippocampusKetamineMalePhosphorylationPsychomotor PerformanceSwimmingTime FactorsReceptors, AMPAalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidExcitatory Amino Acid AntagonistsMice

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Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure