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Telomeres and telomerase: their mechanisms of action and the effects of altering their functions

FEBS Letters · 2004 · Vol. 579(4) · pp. 859–862

Elizabeth H. Blackburn✉(University of California, San Francisco)

Abstract

The molecular features of telomeres and telomerase are conserved among most eukaryotes. How telomerase and telomeres function and how they interact to promote the chromosome-stabilizing properties of telomeres are discussed here.

Telomeres, Telomerase, and Senescence Genetics, Aging, and Longevity in Model Organisms Polar Research and EcologyTelomeraseTelomereTelomerase RNA componentChromosomeEukaryotic chromosome fine structureFunction (biology)Cell biologyBiologyDNAGenetics

MeSH terms

Chromosome AberrationsDNA-Binding ProteinsHumansNeoplasmsTelomereApoptosisTelomerase

Citations

832

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14.87

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References

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

Molecular Cell · 2004 · 1,282 citations

Telomeres and telomerase: their mechanisms of action and the effects of altering their functions

FEBS Letters · 2004 · 832 citations

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