articleTop 10% cited
High throughput artificial membrane permeability assay for blood–brain barrier
European Journal of Medicinal Chemistry · 2003 · Vol. 38(3) · pp. 223–232
Li Di✉(Princeton University)Edward H. Kerns(Princeton University)Kristi Fan(Princeton University)Oliver J. McConnell(Princeton University)Guy T. Carter
Drug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesEpilepsy research and treatmentBlood–brain barrierChemistryHigh-throughput screeningDrug discoveryPermeationPenetration (warfare)MembraneMembrane permeabilitySynthetic membraneDrug
MeSH terms
AnimalsBlood-Brain BarrierBrain ChemistryCell Membrane PermeabilityDrug Evaluation, PreclinicalPharmaceutical PreparationsLipidsMembranes, ArtificialPredictive Value of TestsRoboticsSpectrophotometry, UltravioletSwineReproducibility of ResultsCombinatorial Chemistry TechniquesIn Vitro Techniques
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References
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
Journal of Medicinal Chemistry · 1980 · 812 citations
Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes
Journal of Medicinal Chemistry · 1998 · 1,269 citations
Quantum Calculation of Molecular Energies and Energy Gradients in Solution by a Conductor Solvent Model
The Journal of Physical Chemistry A · 1998 · 9,813 citations
Electrostatic interaction of a solute with a continuum. A direct utilizaion of AB initio molecular potentials for the prevision of solvent effects
Chemical Physics · 1981 · 8,798 citations
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood–brain barrier penetration
Journal of Pharmaceutical Sciences · 1999 · 511 citations
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