articleTop 10% cited
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
Journal of Medicinal Chemistry · 1980 · Vol. 23(6) · pp. 682–684
Abstract
The rat brain capillary permeability coefficient was determined for 27 compounds. The relationship of permeability to octanol/water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400.
Metabolomics and Mass Spectrometry StudiesChemistryPartition coefficientPermeability (electromagnetism)Capillary actionOctanolChromatographyBiochemistryThermodynamicsMembrane
MeSH terms
AnimalsBlood-Brain BarrierBrainCapillary PermeabilityMaleModels, BiologicalMolecular WeightRats, Inbred F344SolubilityStructure-Activity RelationshipRats
Citations
812
FWCI
2.95
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