article Open AccessTop 1% cited

Autophagy in the Pathogenesis of Disease

Cell · 2008 · Vol. 132(1) · pp. 27–42

Beth Levine✉(Southwestern Medical Center)Guido Kroemer✉(Université Paris-Sud)

Autophagy in Disease and TherapyAutophagyNeurodegenerationBiologyDiseaseCell biologyMechanism (biology)NeuroscienceApoptosisGeneticsMedicine

MeSH terms

AgingAnimalsAutophagyCell SurvivalDiseaseHomeostasisHumansLysosomesCell DeathOxidative StressGenomic Instability

Citations

6,967

FWCI

207.20

field-weighted impact

References

104

Percentile

100%

vs. same field & year

Citations per year

Cited by

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Circulation Research · 2018 · 1,950 citations

Inflammatory Bowel Disease

Annual Review of Immunology · 2010 · 1,752 citations

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer

Cells · 2021 · 328 citations

The LIR motif – crucial for selective autophagy

Journal of Cell Science · 2013 · 872 citations

The Double-Edged Sword of Autophagy Modulation in Cancer

Clinical Cancer Research · 2009 · 1,136 citations

Glutathione in Cancer Cell Death

Cancers · 2011 · 307 citations

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

Molecular and Cellular Biology · 2011 · 1,452 citations

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Molecular Biology of the Cell · 2009 · 1,973 citations

References

Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion

Circulation Research · 2007 · 1,476 citations

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Journal of Biological Chemistry · 2007 · 4,501 citations

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Nature Reviews Molecular Cell Biology · 2007 · 3,612 citations

Development by Self-Digestion

Developmental Cell · 2004 · 3,629 citations

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Nature Cell Biology · 2006 · 1,272 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Nature Medicine · 2007 · 2,933 citations

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Molecular Biology of the Cell · 2003 · 2,285 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Journal of Clinical Investigation · 2003 · 2,194 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.