reviewTop 1% cited
Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease
Neurobiology of Aging · 2004 · Vol. 25(5) · pp. 569–580
William L. Klein(Northwestern University)W. Blaine Stine(NorthShore University HealthSystem)David B. Teplow✉(Brigham and Women's Hospital)
Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsProtein foldingPeptideAmyloid (mycology)NeurotoxicityChemistryEffectorNeurodegenerationAlzheimer's diseaseBiochemistryNeuroscience
MeSH terms
AdducinsAlzheimer DiseaseAmino Acid SequenceAnimalsCalmodulin-Binding ProteinsHumansMethionineNeurotoxinsPeptide FragmentsProtein Processing, Post-TranslationalAmyloid beta-PeptidesProtein Folding
Citations
490
FWCI
15.36
field-weighted impact
References
72
Percentile
100%
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Citations per year
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References
High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
Journal of Neuroscience · 2000 · 1,860 citations
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
Journal of Neuroscience · 1993 · 1,424 citations
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
Neuron · 2003 · 4,102 citations
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?
Trends in Neurosciences · 2001 · 994 citations
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
American Journal Of Pathology · 1999 · 1,521 citations
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
Biochemistry · 1993 · 1,996 citations
Psychiatrie: Ein Lehrbuch für Studierende und Ärzte
Journal of the American Medical Association · 1939 · 688 citations
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
Science · 2002 · 13,715 citations
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