reviewTop 1% cited

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse

Neuropharmacology · 2007 · Vol. 53(6) · pp. 699–723

Chris G. Parsons(MerLion Pharma (Germany))Albrecht Stöffler(MerLion Pharma (Germany))Wojciech Danysz✉(MerLion Pharma (Germany))

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Neuroscience and Neuropharmacology Research Medicinal Plants and Neuroprotection Cholinesterase and Neurodegenerative DiseasesMemantineNMDA receptorKainate receptorNeuroscienceNeuroprotectionGlutamatergicAMPA receptorGlutamate receptorPharmacologySynaptic plasticity

MeSH terms

Alzheimer DiseaseDose-Response Relationship, DrugHomeostasisHumansMemantineMemoryMemory DisordersReceptors, N-Methyl-D-AspartateExcitatory Amino Acid Agents

Citations

683

FWCI

15.32

field-weighted impact

References

247

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100%

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References

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Cochrane Database of Systematic Reviews · 2006 · 1,019 citations

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

Neurobiology of Aging · 2007 · 417 citations

Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease

Neurobiology of Aging · 2004 · 490 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

Annals of Neurology · 1994 · 1,030 citations

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

Journal of Neurochemistry · 1984 · 2,877 citations

Neurodegenerative diseases and oxidative stress

Nature Reviews Drug Discovery · 2004 · 3,623 citations

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