article

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

Cellular and Molecular Life Sciences · 1989 · Vol. 45(2) · pp. 209–211

George R. Pettit✉(Arizona State University)Sheo B. Singh(Arizona State University)Ernest Hamel(National Cancer Institute)C. Michael Lin(National Cancer Institute)David S. Alberts(University of Arizona)D. Garcia-Kendal(University of Arizona)

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Synthesis and biological activity Computational Drug Discovery MethodsCombretastatinED50TubulinChemistryMolecular biologyMicrotubuleBiologyBiochemistryCell biologyIn vitro

MeSH terms

AnimalsAntineoplastic Agents, PhytogenicBibenzylsColonic NeoplasmsHumansLeukemia L1210Leukemia P388Magnetic Resonance SpectroscopyPlant ExtractsMass SpectrometryStilbenesTumor Cells, CulturedMolecular StructureTubulin ModulatorsMice

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785

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3.02

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89%

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Recent advances in the synthesis of (hetero)aryl-substituted heteroarenes via transition metal-catalysed direct (hetero)arylation of heteroarene C–H bonds with aryl halides or pseudohalides, diaryliodonium salts, and potassium aryltrifluoroborates