article Open AccessTop 10% cited
Potent antimitotic and cell growth inhibitory properties of substituted chalcones
Bioorganic & Medicinal Chemistry Letters · 1998 · Vol. 8(9) · pp. 1051–1056
Sylvie Ducki(University of Manchester)Richard Forrest(University of Manchester)John A. Hadfield(Cancer Research UK Manchester Institute)Alex Guy Kendall(University of Manchester)Nicholas J. Lawrence✉(University of Manchester)Alan T. McGown(The Christie NHS Foundation Trust)David Rennison(Cancer Research UK Manchester Institute)
Synthesis and biological activitySynthesis and Biological EvaluationFungal Plant Pathogen ControlChemistryCytotoxicityChalconeStereochemistryK562 cellsCytotoxic T cellCell cultureIC50Chemical synthesisStructure–activity relationship
MeSH terms
Antineoplastic AgentsCell CycleCell DivisionCell SurvivalChalconeHumansModels, MolecularMolecular ConformationStructure-Activity RelationshipDrug DesignMolecular StructureCrystallography, X-RayK562 Cells
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366
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Cited by
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European Journal of Medicinal Chemistry · 2015 · 487 citations
References
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
Cellular and Molecular Life Sciences · 1989 · 785 citations
Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum
Journal of Natural Products · 1987 · 320 citations
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