article Open AccessTop 1% cited

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

Cell Metabolism · 2014 · Vol. 20(1) · pp. 61–72

Andrew N. Macintyre✉(Duke University)Valerie A. Gerriets(Duke University)Amanda Nichols(Duke University)Ryan D. Michalek(Duke University)Michael C. Rudolph(University of Colorado Anschutz Medical Campus)Divino Deoliveira(Duke University)Steven M. Anderson(University of Colorado Anschutz Medical Campus)E. Dale Abel(University of Iowa)Benny J. Chen(Duke University)Laura P. Hale(Duke University)Jeffrey C. Rathmell(Duke University)

View via DOI Full-text PDF

Immune Cell Function and Interaction Metabolism, Diabetes, and Cancer Cancer Immunotherapy and BiomarkersGLUT1Glucose transporterEffectorIn vivoGlycolysisCell biologyBiologyGlucose uptakeT cellGlucose Transporter Type 1

MeSH terms

AnimalsCell SurvivalColitisGlucoseGlycolysisT-Lymphocytes, Helper-InducerHumansMice, Inbred BALB CMice, Inbred C57BLRNA, MessengerTransplantation, HomologousCD4-Positive T-LymphocytesMice, KnockoutHomeodomain ProteinsT-Lymphocytes, Regulatory

Citations

1,108

FWCI

26.77

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

CD69: from activation marker to metabolic gatekeeper

European Journal of Immunology · 2017 · 913 citations

Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions

Frontiers in Immunology · 2015 · 996 citations

Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments

Cell Metabolism · 2017 · 1,139 citations

References

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Immunity · 2011 · 1,474 citations

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Molecular Cell · 2010 · 1,954 citations

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

Immunity · 2011 · 2,061 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

Immunity · 2002 · 1,417 citations

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Science · 2009 · 15,796 citations

Glucose transporters in the 21st Century

American Journal of Physiology-Endocrinology and Metabolism · 2009 · 993 citations

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

American Journal of Physiology-Cell Physiology · 2006 · 919 citations

Differentiation of Effector CD4 T Cell Populations

Annual Review of Immunology · 2010 · 3,378 citations

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer

Journal of Cellular Physiology · 2004 · 1,237 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.