articleTop 1% cited
Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers
JNCI Journal of the National Cancer Institute · 2005 · Vol. 97(5) · pp. 339–346
Hisayuki Shigematsu✉(The University of Texas MD Anderson Cancer Center)Lin Li(Chiba University)Tsuyoshi Takahashi(Okayama University)Masatoshi Nomura(Okayama University)M. Suzuki(Fred Hutch Cancer Center)I. Wistuba(The University of Texas Southwestern Medical Center)Kwun M. Fong(Fred Hutch Cancer Center)Hai Quan Lee(The University of Texas MD Anderson Cancer Center)Shinichi Toyooka(Chiba University)Nobutaka Shimizu(Prince Charles Hospital)Takehiko Fujisawa(Chung Shan Medical University)Ziding Feng(Fred Hutch Cancer Center)Jack A. Roth(Chung Shan Medical University)Joachim Herz(Prince Charles Hospital)J D Minna(Okayama University)Adi F. Gazdar(Prince Charles Hospital)
Abstract
Mutations in either the EGFR TK domain or the KRAS gene can lead to lung cancer pathogenesis. EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers.
Lung Cancer Treatments and MutationsLung Cancer Research StudiesPI3K/AKT/mTOR signaling in cancerEpidermal growth factor receptorKRASLung cancerLungCancer researchMedicineMutationEpidermal growth factorGene mutationExon
MeSH terms
AdenocarcinomaAustraliaCarcinoma, Non-Small-Cell LungDNA, ViralFemaleHumansJapanLung NeoplasmsMaleMutationNeoplasm StagingProtein-Tyrosine KinasesGenes, rasTaiwanUnited States
Citations
2,385
FWCI
122.21
field-weighted impact
References
44
Percentile
100%
vs. same field & year
Citations per year
Cited by
The prevalence of <i>EGFR</i> mutation in patients with non-small cell lung cancer: a systematic review and meta-analysis
Oncotarget · 2016 · 768 citations
Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor <i>EML4-ALK</i>
Journal of Clinical Oncology · 2009 · 1,873 citations
Cancer health disparities in racial/ethnic minorities in the United States
British Journal of Cancer · 2020 · 879 citations
Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification
Frontiers in Oncology · 2017 · 485 citations
Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain
PLoS Medicine · 2005 · 3,519 citations
Epidermal growth factor receptor mutations in lung cancer
Nature reviews. Cancer · 2007 · 3,115 citations
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
International Journal of Cancer · 2005 · 661 citations
The biology and treatment of EML4-ALK non-small cell lung cancer
European Journal of Cancer · 2010 · 556 citations
References
Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer
JNCI Journal of the National Cancer Institute · 2005 · 1,568 citations
Revisions in the International System for Staging Lung Cancer
CHEST Journal · 1997 · 4,599 citations
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
New England Journal of Medicine · 2004 · 11,455 citations
Cancer Statistics, 2004
CA A Cancer Journal for Clinicians · 2004 · 4,003 citations
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
Proceedings of the National Academy of Sciences · 2004 · 4,332 citations
Multi-Institutional Randomized Phase II Trial of Gefitinib for Previously Treated Patients With Advanced Non–Small-Cell Lung Cancer
Journal of Clinical Oncology · 2003 · 2,883 citations
<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Science · 2004 · 9,380 citations
Mutations of the BRAF gene in human cancer
Nature · 2002 · 10,619 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.