review Open AccessTop 10% cited
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
Molecules · 2008 · Vol. 13(8) · pp. 1551–1569
Ning Zhang(Zhejiang University)Ying Yin(Zhejiang University)Shengjie Xu(Sir Run Run Shaw Hospital)Weishan Chen✉(Zhejiang University)
Abstract
The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.
Colorectal Cancer Treatments and StudiesGastric Cancer Management and OutcomesCancer Research and TreatmentsFluorouracilDrug resistanceMicroarrayResistance (ecology)Identification (biology)Computational biologySite of actionMicroarray analysis techniquesAction (physics)Bioinformatics
MeSH terms
Antineoplastic AgentsFluorouracilHumansDrug Resistance, NeoplasmGene Expression Profiling
Citations
764
FWCI
3.11
field-weighted impact
References
126
Percentile
92%
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Citations per year
Cited by
Drug Resistance in Cancer: An Overview
Cancers · 2014 · 2,424 citations
References
5-Fluorouracil: mechanisms of action and clinical strategies
Nature reviews. Cancer · 2003 · 5,181 citations
Molecular mechanisms of drug resistance
The Journal of Pathology · 2005 · 1,646 citations
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