articleTop 10% cited
Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle
Dalton Transactions · 2012 · Vol. 41(23) · pp. 6906–6906
Chunyi SunChao Qin(Northeast Normal University)Xinlong Wang✉(Northeast Normal University)Guang‐Sheng Yang(Northeast Normal University)Kui‐Zhan Shao(Northeast Normal University)Ya‐Qian Lan(Northeast Normal University)Zhong‐Min Su✉(Northeast Normal University)Peng Huang(Northeast Normal University)Chungang Wang(Northeast Normal University)En‐Bo Wang(Northeast Normal University)
Abstract
Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.
Metal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsCovalent Organic Framework ApplicationsZeolitic imidazolate frameworkImidazolateDrug deliveryDrugAnticancer drugChemistryNanotechnologyCombinatorial chemistryMetal-organic frameworkMaterials science
MeSH terms
Antineoplastic AgentsDrug CarriersFluorouracilHydrogen-Ion ConcentrationImidazolesModels, MolecularMolecular ConformationZeolites
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References
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Nature reviews. Cancer · 2003 · 5,181 citations
From Microporous to Mesoporous Molecular Sieve Materials and Their Use in Catalysis
Chemical Reviews · 1997 · 5,716 citations
Enantioselective catalysis with homochiral metal–organic frameworks
Chemical Society Reviews · 2009 · 3,103 citations
Exceptional chemical and thermal stability of zeolitic imidazolate frameworks
Proceedings of the National Academy of Sciences · 2006 · 7,256 citations
Hydrogen storage in metal–organic frameworks
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