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Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

Biochemical and Biophysical Research Communications · 2000 · Vol. 273(2) · pp. 793–798

Roy A. Frye✉(University of Pittsburgh Medical Center)

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Sirtuins and Resveratrol in Medicine Toxin Mechanisms and Immunotoxins Plant biochemistry and biosynthesisSirtuinBiologySIRT2SIRT3Phylogenetic treeCaenorhabditis elegansDrosophila melanogasterSaccharomyces cerevisiaeGeneGenetics

MeSH terms

Amino Acid SequenceAnimalsDrosophila melanogasterEukaryotic CellsHistone DeacetylasesHumansModels, GeneticMolecular Sequence DataPhylogenyProkaryotic CellsTrans-ActivatorsConserved SequenceSequence Homology, Amino AcidProtein Structure, TertiaryDNA, Complementary

Funding

U.S. Department of Veterans Affairs

Citations

1,387

FWCI

31.22

field-weighted impact

References

21

Percentile

100%

vs. same field & year

Citations per year

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References

ORIGIN OF EUKARYOTIC CELLS

Evolution · 1971 · 1,176 citations

Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

Biochemical and Biophysical Research Communications · 1999 · 805 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Genes & Development · 1999 · 2,256 citations

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