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Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

British Journal of Dermatology · 2008 · Vol. 159(5) · pp. ???–???

Kristine Nograles✉(Rockefeller University)Lisa C. ZabaEmma Guttman‐YasskyJudilyn Fuentes‐DuculanMayte Suárez‐FariñasIrma CardinaleArtemis KhatcherianJuana GonzalezKatherine C. PiersonTraci R. WhiteCara A. PensabeneIsrael CoatsInna NovitskayaMichelle A. LowesJames G. Krueger

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Abstract

Our results suggest that the Th17 cytokines IL-17 and IL-22 mediate distinct downstream pathways that contribute to the psoriatic phenotype: IL-17 is more proinflammatory, while IL-22 retards keratinocyte differentiation.

Psoriasis: Treatment and Pathogenesis Dermatology and Skin Diseases Asthma and respiratory diseasesCytokineInterleukin 20ImmunologyKeratinocyteProinflammatory cytokineChemokineBiologyCytokine receptorInterleukinPsoriasis

MeSH terms

Interleukin-22Chronic DiseaseFlow CytometryFluorescent Antibody TechniqueHumansImmunohistochemistryInterferon-gammaInterleukinsPsoriasisT-LymphocytesKeratinocytesCytokinesReverse Transcriptase Polymerase Chain ReactionInterleukin-17Tissue Array Analysis

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796

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Cited by

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis