articleTop 1% cited
A Systematic Evaluation of the Effect of Temperature on Coagulation Enzyme Activity and Platelet Function
The Journal of Trauma: Injury, Infection, and Critical Care · 2004 · Vol. 56(6) · pp. 1221–1228
Alisa S. Wolberg✉(University of North Carolina at Chapel Hill)Zhi Hong MengDougald M. MonroeMaureane Hoffman(Durham VA Medical Center)
Abstract
Our results suggest that bleeding observed at mildly reduced temperatures (33 degrees - 37 degrees C) results primarily from a platelet adhesion defect, and not reduced enzyme activity or platelet activation. However, at temperatures below 33 degrees C, both reduced platelet function and enzyme activity likely contribute to the coagulopathy.
Thermal Regulation in MedicineCardiac Arrest and ResuscitationTrauma, Hemostasis, Coagulopathy, ResuscitationPlateletFibrinolysisPlatelet activationCoagulopathyCoagulationPartial thromboplastin timeMedicineInternal medicineHypothermiaEnzyme
MeSH terms
AdultBlood CoagulationHumansHypothermiaMiddle AgedPartial Thromboplastin TimePlatelet AdhesivenessPlatelet AggregationTemperatureThrombinFactor Xa
Citations
525
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16.93
field-weighted impact
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42
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The Coagulopathy of Trauma: A Review of Mechanisms
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References
Hypothermia in Trauma Victims
The Journal of Trauma: Injury, Infection, and Critical Care · 1987 · 680 citations
Reversible Inhibition of Human Platelet Activation by Hypothermia In Vivo and In Vitro
Thrombosis and Haemostasis · 1994 · 401 citations
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