articleTop 1% cited
Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism
Journal of Pharmacology and Experimental Therapeutics · 1997 · Vol. 283(3) · pp. 1552–1562
Mary F. Paine✉(University of Washington)Mehraneh Khalighi(University of Washington)Jeannine M. Fisher(University of Washington)Danny D. Shen(University of Washington)Kent L. Kunze(University of Washington)Christopher L. Marsh(University of Washington)James D. Perkins(University of Washington)Kenneth E. Thummel(University of Washington)
Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsDrug-Induced Hepatotoxicity and ProtectionCYP3AIleumJejunumDuodenumMicrosomeMidazolamInternal medicineChemistryEndocrinologyBiology
MeSH terms
Aryl Hydrocarbon HydroxylasesCytochrome P-450 Enzyme SystemHumansHydroxylationIntestinal MucosaLiverMetabolic Clearance RateMidazolamOxidoreductases, N-DemethylatingCytochromes b5Cytochrome P-450 CYP3A
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51
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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
Journal of Pharmacology and Experimental Therapeutics · 1994 · 2,779 citations
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